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CAS No.: 472-15-1

白桦脂酸 Catalog No. CSN12619

Synonyms: 白桦脂酸;Lupatic acid;Betulic acid

Betulinic acid, a pentacyclic triterpene isolated and purified from the herbs of Ziziphus jujuba, selectively induces apoptosis in tumor cells, also is an inhibitor of HIV-1 with EC50 of 1.4 μ M.

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技术信息

生物活性

描述Betulinic Acid is a natural pentacyclic triterpenoid compound and a eukaryotic topoisomerase I inhibitor with IC50 value of 0.5 mM. It has anti-inflammatory, anti malaria, anti AIDS and anti-tumor activities^[3]. Betulinic Acid is also a new activator of NF κB^[4]. Betulinic Acid (20, 40 µM) causes decrease in Bcl-2 expression of MDA-MB-231 cells^[5]. Betulinic Acid has anti HIV activity. EC50 of H9 lymphocytes infected with Betulinic Acid is 1.4 μ M^[6]. Moreover, oral administration of Betulinic Acid reduced the bleeding score at 10 and 30 mg/kg and improved the stool consistency at 30 mg/kg^[7].
临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00346502	Dysplastic Nevus Syndrome	Phase 1 Phase 2	Suspended(The study has been t... more >>emporarily suspended due to funding issues) Collapse <<	December 2015	United States, Illinois ... more >> University of Illinois at Chicago Medical Center Chicago, Illinois, United States, 60612 Collapse <<

参考文献

实验方案

计算器摩尔计算器总药量计算器工作液计算器
储存液制备
- 1 mg
- 5 mg
- 10 mg
- 1 mM
- 2.1896 mL
- 10.9481 mL
- 21.8962 mL
- 5 mM
- 0.4379 mL
- 2.1896 mL
- 4.3792 mL
- 10 mM
- 0.2190 mL
- 1.0948 mL
- 2.1896 mL

技术信息

CAS号

472-15-1

储存条件

粉末: Sealed in dry,2-8°C

液体: -20°C:3-6 月 -80°C:12月

分子式

C30H48O3

运输

蓝冰

分子量

456.70

别名

白桦脂酸;Lupatic acid;Betulic acid

溶解度

DMSO	18.0 mg/mL (39.4 mM)
Water	Insoluble
Ethanol	10.0 mg/mL (21.9 mM)

动物实验配方

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